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swyx + Alessio · Technology

Latent Space: The AI Engineer Podcast

The podcast by and for AI Engineers! In 2025, over 10 million readers and listeners came to Latent Space to hear about news, papers and interviews in Software 3.0. We cover Foundation Models changing every domain in Code Generation, Multimodality, AI Agents, GPU Infra and more, directly from the founders, builders, and thinkers involved in pushing the cutting edge. Striving to give you both the definitive take on the Current Thing down to the first introduction to the tech you'll be using in the next 3 months! We break news and exclusive interviews from OpenAI, Anthropic, Gemini, Meta (Soumith Chintala), Sierra (Bret Taylor), tiny (George Hotz), Databricks/MosaicML (Jon Frankle), Modular (Chris Lattner), Answer.ai (Jeremy Howard), et al. Full show notes always on https://latent.space Sponsorship and business inquiries: [email protected] www.latent.space

Episodes

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Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion

15 Apr 2026
1h 17m
AI processed

Notion’s approach to building AI agents centers on a "software factory" model that prioritizes iterative prototyping, developer velocity, and deep integration with the company's existing data primitives. By treating agents as autonomous systems capable of self-verification and debugging, the team has moved away from ri...

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Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony

07 Apr 2026
1h 12m
AI processed

The discussion centers on Harness engineering, a methodology for AI-driven software development, with Ryan Lopopolo from OpenAI. Lopopolo details his team's experience building an internal tool using AI agents that wrote over a million lines of code with minimal human intervention. A key aspect involves inverting contr...

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Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"

03 Apr 2026
1h 16m
AI processed

The discussion centers on the transformative potential of AI, particularly its current state as an "80-year overnight success" built on decades of research. It highlights the shift from pattern completion to reasoning and coding breakthroughs, with AI now capable of real-world applications. The conversation explores AI...

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Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun

02 Apr 2026
1h 6m
AI processed

Moonlake's founders, Fan-yun Sun and Chris Manning, discuss their approach to building world models, emphasizing structure and reasoning over pure scale. They differentiate their work from video generation models like Sora by focusing on action-conditioned models that predict the consequences of actions over longer tim...

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Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample

30 Mar 2026
48m
AI processed

Mistral AI's release of Voxtral TTS, their first speech generation model, is the central focus, with Guillaume Lample and Pavan Kumar Reddy from Mistral detailing its architecture and capabilities. The model supports nine languages, is cost-effective, and uses a novel autoregressive flow matching architecture with a ne...

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🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik

24 Mar 2026
35m
AI processed

The podcast explores the application of AI and machine learning in accelerating the discovery of new materials, particularly in chemistry. Heather Kulik, a professor of chemical engineering at MIT, shares her work on using AI to predict and optimize material properties, such as making tougher plastics by uncovering une...

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Dreamer: the Personal Agent OS — David Singleton

20 Mar 2026
1h 3m
AI processed

Dreamer, a platform for building and using AI agents and agentic apps, aims to make AI accessible to everyone, including non-technical users. David Singleton, former CTO of Stripe and co-founder of Dreamer, details how the platform allows users to discover, build, and utilize AI agents through a personal agent called S...

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Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop

17 Mar 2026
1h 26m
AI processed

The Latent Space podcast features Felix Rieseberg from Anthropic, who discusses Claude Cowork, a user-friendly version of Cloud Code. Rieseberg explains that Cowork allows non-technical users to leverage Cloud Code for tasks like managing expenses and organizing knowledge bases. He draws parallels between Cowork and Vi...

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Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer

12 Mar 2026
1h 0m
AI processed

Turbopuffer's origin story and architecture are explored with Simon Eskildsen, delving into its evolution as a search engine for unstructured data. Eskildsen details Turbopuffer's unique approach to database architecture, leveraging NVMe SSDs and object storage, and its reliance on S3's consistency for consensus. He re...

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NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)

10 Mar 2026
1h 23m
AI processed

The Latent Space Podcast explores the evolving landscape of AI development, developer experience, and the future of inference. Nader Khalil and Kyle Kranen from NVIDIA discuss the acquisition of Brev, a developer tool for GPU access, and NVIDIA's broader strategy in developer experience, emphasizing the importance of u...

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Cursor's Third Era: Cloud Agents

06 Mar 2026
1h 6m
AI processed

The podcast explores Cursor's Cloud Agents, focusing on how they enhance software development workflows through automation and collaboration. A key innovation is the agent's ability to test its own code and provide a video demo of the changes, streamlining the review process. The discussion highlights three pillars: mo...

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Every Agent Needs a Box — Aaron Levie, Box

05 Mar 2026
1h 16m
AI processed

The podcast explores the transformative impact of AI agents on enterprise workflows, focusing on the challenges and opportunities in managing and securing agent access to corporate data. It highlights the shift from humans actively engaging with files to AI agents continuously utilizing data for various tasks, such as ...

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METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity

27 Feb 2026
56m
AI processed

METR's Joel Becker joins the Latent Space Podcast to discuss AI model evaluation and threat research, focusing on METR's work in assessing AI capabilities and propensities. Becker addresses the "Time Horizon" chart, explaining its origins and the methodology behind task selection, emphasizing the focus on economically ...

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[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka

26 Feb 2026
52m
AI processed

The podcast explores the ethics and practicalities of "distillation attacks" on large language models (LLMs), where smaller models are trained on the outputs of larger, proprietary models. The discussion covers the challenges of detecting such attacks versus legitimate evaluation, noting that scale and pattern analysis...

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🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI

25 Feb 2026
33m
AI processed

The podcast explores the intersection of AI and material science, particularly regarding climate change and new materials discovery. Max Welling discusses his career evolution from theoretical physics to AI, driven by a desire to make a tangible impact. He introduces CuspAI, his startup focused on using AI to accelerat...

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Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis

24 Feb 2026
2h 4m
AI processed

Doug O'Laughlin of SemiAnalysis joins Latent Space to discuss the transformative impact of AI, particularly Claude Code, on information work and the semiconductor industry. O'Laughlin details his journey from value investing to semiconductor analysis, highlighting the pivotal insight that Moore's Law was ending, which ...

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⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data

23 Feb 2026
26m
AI processed

The podcast explores the limitations of the SWE-Bench Verified benchmark in evaluating coding progress due to saturation and contamination. Mia Glaese and Olivia Watkins from OpenAI discuss the original effort to create SWE-Bench Verified, involving extensive reviews by software engineers to ensure fair problem setups ...

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Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z

19 Feb 2026
55m
AI processed

The Latent Space podcast explores the evolving landscape of AI investment, focusing on the blurring lines between venture and growth, and infrastructure and applications. Sarah Wang and Martin Casado from A16Z discuss the unique capital flywheel in AI, where companies raise money for compute, achieve breakthroughs, and...

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Owning the AI Pareto Frontier — Jeff Dean

12 Feb 2026
1h 23m
AI processed

Jeff Dean, Chief AI Scientist at Google, joins the Latent Space Podcast to discuss the balance between frontier AI model capabilities and the practical need for efficient, deployable models. Dean emphasizes that both high-end and affordable models are crucial, with distillation techniques bridging the gap. The conversa...

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🔬Beyond AlphaFold: How Boltz is Open-Sourcing the Future of Drug Discovery

12 Feb 2026
1h 21m
AI processed

Boltz, co-founded by Gabriele Corso and Jeremy Wohlwend, aims to democratize structural prediction in biology. The discussion centers on the transformative impact of AlphaFold and AlphaFold 3 on protein structure prediction and the challenges of modeling protein interactions. CASP competitions are highlighted as benchm...

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