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03 Nov 2026
1h 11m

The Art of Aging: What Every Woman Should Know About Her Brain

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Next Question with Katie Couric

Women’s brain health undergoes significant changes during menopause, yet scientific research has historically neglected the biological differences between men and women. Dr. Rhonda Voskuhl, a neurologist and expert in women’s brain health, highlights that the abrupt loss of estrogen at midlife impacts the hippocampus and frontal cortex, leading to cognitive issues like memory lapses and reduced processing speed. While traditional estradiol patches help manage acute symptoms like hot flashes, they often fail to address long-term cognitive decline. Effective intervention requires personalized approaches, including potential next-generation estrogens like estriol that target specific receptors to protect brain cells without increasing breast cancer risks. Beyond hormonal therapy, maintaining brain health necessitates rigorous cardiovascular exercise, cognitive training tailored to specific deficits, and proactive monitoring of biomarkers to mitigate risks for conditions like Alzheimer’s disease.

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