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How Hops Extract Suppresses Hunger, Reduces Cravings, Supports Weight Loss, and Makes Intermittent Fasting Easier

Host Dave Asprey sits down with Sarah Kennedy, CEO of Calocurb, to explore the surprising science of hunger suppression, natural GLP-1 activation, intermittent fasting, weight loss, visceral fat reduction, and a patented hops extract that may help people eat less without relying on willpower.

The conversation centers on Amarasate, a natural compound derived from New Zealand hops, the same plant used to make beer. Originally investigated through a multimillion-dollar research program, this bitter plant extract activates specialized receptors in the digestive tract that stimulate the body's natural appetite-regulating hormones. Sarah explains how this discovery led to Calocurb, a supplement designed to reduce hunger, control cravings, and make fasting and calorie restriction easier.

Dave and Sarah break down the biology of GLP-1, CCK, PYY, ghrelin, and leptin, exploring how these hormones influence hunger, fullness, food cravings, and metabolic health. Unlike injectable GLP-1 medications such as Ozempic and Wegovy, Amarasate works through bitter taste receptors in the gut to stimulate the body's own satiety signaling. They examine why the timing and location of these signals matter, how quickly the extract begins working, and what distinguishes this approach from conventional appetite suppressants.

Sarah shares findings from four human clinical trials, including research reporting an average 18% reduction in calorie intake following consumption of the hops extract. They discuss how activating gut receptors can influence eating behavior, why some people struggle with persistent hunger despite consuming enough calories, and how manipulating the body's natural fullness signals could change approaches to weight management.

The discussion also examines a six-month randomized, placebo-controlled study involving approximately 150 participants, which reported an average 5.5% reduction in body weight, with estimated fat loss and no detected average muscle loss. Sarah describes findings suggesting approximately 3.5 times greater visceral fat reduction compared with placebo, raising questions about whether targeted appetite regulation could support healthier body composition. Dave and Sarah explore why preserving lean muscle while reducing abdominal fat is especially important for metabolic health, healthy aging, and longevity.

They also explore how hops extract may make intermittent fasting and extended fasting easier by reducing hunger and food cravings. Dave discusses the practical challenges of fasting, while Sarah explains how bitter receptor activation can help people manage appetite without constantly fighting the urge to eat. They examine the potential applications for time-restricted eating, longer fasting windows, calorie control, and sustainable weight management.

Finally, Dave and Sarah challenge conventional assumptions about willpower, hunger, and obesity, exploring why overeating is not simply a failure of discipline. They discuss the relationship between gut-brain signaling, metabolic hormones, food intake, and the emerging science of naturally regulating appetite, including how plant-derived compounds could complement nutrition, exercise, and other metabolic health strategies.

This episode is essential listening for anyone interested in natural appetite suppression, hops extract, intermittent fasting, GLP-1, hunger hormones, weight loss, visceral fat, muscle preservation, metabolic health, gut-brain signaling, and science-backed strategies for controlling cravings and eating less.

You'll Learn:

How a patented compound extracted from hops activates bitter receptors in the gut to stimulate GLP-1, CCK, and PYY, the hormones involved in hunger and fullness
Why clinical research found that hops extract reduced calorie intake by approximately 18%, and what that means for appetite control and overeating
How a six-month clinical trial reported 5.5% body-weight loss, reduced visceral fat, and no detected average muscle loss
Why hunger, cravings, and overeating involve complex hormonal signaling rather than simply a lack of willpower
How natural appetite regulation may make intermittent fasting, extended fasting, and calorie restriction easier to maintain
How hops-derived compounds differ from injectable GLP-1 medications, and what the research suggests about their potential role in weight management

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Sarah Kennedy, Sarah Kennedy Calocurb, Dave Asprey, The Human Upgrade, Calocurb, Amarasate, hops extract, hops weight loss, hops appetite suppressant, natural appetite suppressant, natural hunger suppressant, stop overeating, reduce hunger, control cravings, food cravings, hunger control, weight loss, fat loss, visceral fat reduction, belly fat, muscle preservation, lean muscle mass, GLP-1, natural GLP-1, GLP-1 activation, GLP-1 alternatives, Ozempic, Wegovy, CCK, cholecystokinin, PYY, peptide YY, ghrelin, leptin, hunger hormones, satiety hormones, bitter taste receptors, gut-brain axis, gut-brain signaling, intermittent fasting, fasting without hunger, extended fasting, time-restricted eating, fasting made simple, calorie restriction, calorie intake reduction, metabolic health, obesity, weight management, body composition, fat loss without muscle loss, biohacking, longevity, natural weight loss supplements

Resources:

• Calocurb | Use Dave10 at calocurb.com to get a discount

• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.

• Danger Coffee: https://dangercoffee.com/discount/davetube

• My Daily Supplements: SuppGrade Labs (15% Off)

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

Thank you to our sponsors!

- Simplify | This episode is sponsored by Simplify. You’ve built your nest egg. Now see how XV can help you put it to work. Visit Simplify.us/NestEgg to learn more.

- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.

- Mars Men | For a limited time, our listeners get 50% off FOR LIFE, Free Shipping, AND 3 Free Gifts at Mars Men at Mengotomars.com.

- Neuronic | Go to www.neuronic.online Code DAVE for $100 off

Timestamps:

00:00 - Trailer

01:32 - Intro

03:06 - Discovering Hops Extract

07:58 - Finding the Right Hop

10:15 - Clinical Trial Results

15:34 - No Rebound Weight Gain

19:47 - Personal Story & Fasting

23:05 - Women's Fasting Study

29:32 - Willpower & Hunger

38:42 - Combining With GLP-1s

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The No-Brainer Solution To Stop Overeating : 1565

The Human Upgrade: Biohacking for Longevity & Performance

The No-Brainer Solution To Stop Overeating : 1565