You can eat clean, track your labs, take supplements, and still feel anxious, inflamed, tired, or flat. Why? Because the gut, brain, immune system, and hormones are in constant conversation, and most of us are only treating one side of that story.

In this episode of Extend, I sit down with Dr. Will Cole to uncover the science behind the gut-brain axis, and why nervous system dysregulation might be the reason your biomarkers won't budge. We unpack how microbiome imbalances, silent inflammation, low vagal tone, and stored trauma show up as anxiety, constipation, brain fog, and burnout… even when you're "doing everything right."

We also get practical: testing beyond standard blood work, HRV as a window into resilience, breathwork vs. meditation, EMDR, "ugly journaling," and when devices like Apollo Neuro and Sensate actually help.

Dr. Will Cole is a leading functional medicine expert, a pioneer in gut-brain health, neuroimmune disorders, and autoimmune healing. He is also the host of the top-ranked podcast The Art of Being Well and the New York Times bestselling author of books including Gut Feelings, The Inflammation Spectrum, and Ketotarian.

What's Discussed:

(00:00) From Functional Medicine to the Gut-Brain Revolution
(13:14) How Trauma, Serotonin, and the Vagus Nerve Shape the Mind-Gut Connection
(21:13) Healing the Nervous System: Journaling, EMDR, and Wearable Vagus Nerve Tech
(30:15) Why Real Health Change Starts with Individuals, Not Institutions
(35:07) Food Deserts, Misinformation, and Taking Your Health Back
(43:04) Regenerative Supplements, Soil Health & The Future of Functional Medicine

Thank You for Our Sponsors:

IM8: Try IM8 today with a 30-day money back guarantee. You can get 10% off your first order with code DRSHAH at https://im8health.com/discount/DRSHAH.
Vitaboom: For supplements you can trust and wellness solutions tailored to your health, visit https://vitaboom.com/

Learn more about Dr. Shah:

Website: https://www.drshah.com/

Clinic: https://www.next-health.com/

Instagram:@darshanshahmd

Learn more about Dr. Will Cole:

Instagram: @drwillcole
Instagram: @theartofbeingwell_

Youtube: @DrWillCole

107. Dr. Will Cole: Gut Issues and Anxiety? Functional Medicine Is Finally Connecting the Dots

Extend Podcast with Darshan Shah, MD

107. Dr. Will Cole: Gut Issues and Anxiety? Functional Medicine Is Finally Connecting the Dots