If you think your skincare routine is protecting your skin, this conversation may make you look at your bathroom shelf differently. You've been taught to treat your skin like something cosmetic, something you maintain for how it looks. But your skin is your largest organ, it has its own biological age, and if you are not supporting it properly, it can become a constant source of inflammation and damage that goes far beyond appearance.

We dive deeper into this in Extend with Carolina Reis de Oliveira, PhD. We also break down why most skincare products are not built to target the biology of aging, how senescent cells drive visible and invisible skin aging, and how OS-01, discovered through machine learning, is designed to slow the spread of these dysfunctional cells so you can actually support your skin as part of your longevity strategy.

Carolina Reis de Oliveira, PhD, is a stem cell biologist, tissue engineer, and co-founder and CEO of OneSkin. She has spent over a decade researching cellular aging, building human skin models in the lab, and developing epigenetic clocks to measure biological skin age, with her work on OS-01 validated through peer-reviewed research, making her one of the leading voices translating longevity science into real-world applications for skin.

For a limited time, you can try OneSkin for 15% off with code EXTEND at oneskin.co/EXTEND That's 15% off oneskin.co with code EXTEND

What's Discussed:

(2:02) Why OneSkin started by asking what actually targets skin aging at the cellular level.
(4:02) How popular anti-aging products can cause inflammation and damage.
(9:25) The three main drivers of skin aging: senescence, inflammation, and collagen breakdown.
(11:24) Why UV exposure is responsible for most visible skin aging.
(21:33) How OS-01 was discovered through machine learning and peptide screening.
(26:33) Why too many actives can overwhelm the skin instead of helping it.
(32:58) How aging skin can contribute to inflammation inside the body.
(37:12) How skin biological age can be measured with epigenetic clocks.

Listen to this episode of Extend with Darshan Shah, MD on Apple Podcasts or Spotify to understand why skin is not just cosmetic, what actually drives skin aging at the cellular level, and how to start treating your skin like the longevity organ it really is.

Thank You to Our Sponsors:

Timeline: Timeline powered by Mitopure just dropped the price. Check it out at timeline.com/drshah and get an additional 20% off your first month with code DRSHAH.

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Learn more about Dr. Darshan Shah:

Website: drshah.com

Clinic: next-health.com

Instagram: darshanshahmd

Learn more about OneSkin:

Website: www.oneskin.co/

Instagram: @oneskin.co

TikTok: @oneskin.co

166. Carolina Reis de Oliveira: The Missing Link Between Skin and Longevity

Extend Podcast with Darshan Shah, MD

166. Carolina Reis de Oliveira: The Missing Link Between Skin and Longevity