In this episode, Sam Ashoo, MD and Dr. T.R. Eckler, MD discuss the September 2026 Emergency Medicine Practice article, Emergency Department Diagnosis and Management of Acetaminophen or Salicylate Toxicity

1:13 — Welcome and topic introduction

3:50 — Key rules: check levels, call Poison Control

5:13 — Acetaminophen pathophysiology

8:16 — Salicylate pathophysiology

10:51 — Coingestions

11:11 — Differential diagnosis

12:19 — History & pre-hospital care

15:28 — Product confusion

17:08 — Toxic dose thresholds

18:26 — Physical exam & vital signs

20:16 — Acetaminophen toxicity stages (1-4)

22:35 — Salicylate exam findings

23:43 — Lab workup & testing

24:45 — Acetaminophen nomogram & levels

30:39 — Activated charcoal — when to give it

34:11 — NAC therapy — dosing & timing

37:22 — Hemodialysis for acetaminophen

38:40 — King's College Criteria

41:00 — Salicylate treatment

44:42 — Potassium management during alkalinization

47:28 — Hemodialysis for salicylate

48:05 — Intubation

50:00 — Pregnancy considerations

51:20 — Pediatric considerations

52:06 — Emerging: fomepizole as adjunct therapy

52:45 — Summary & wrap-up

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Acetaminophen and Salicylate Toxicity

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