This was written with some assistance from Claude Fable 5, Opus 5.5, and GPT-6 Astra in collecting sources and fact-checking claims. This was written quickly, so some slop may leak through despite my best attempts.

An Aperitif

Consider hunger, that gnawing thing. Action Against Hunger describes it as “the distress associated with a lack of food”. But this is a plain recounting of something rich and multi-dimensional; people have done horrendous, outrageous things to avoid going hungry, hunger is so deep a metaphor that it is often used to represent another intense, unfulfilled craving.

Van Gogh's The Potato Eaters, 1885.

In mice, you can excite about 800 neurons to evoke voracious feeding within minutes (Aponte et al. 2011). In humans, semaglutide, the active ingredient in Ozempic, acts on GLP-1 receptors and reduces hunger and food cravings. So, something as rich as hunger can be influenced and manipulated through a rather simple and fixed intervention.

This is because there is already much complexity in the system being influenced. A mouse already possesses the machinery to recognize, approach, and eat food, so do humans. Instead, to intervene, one merely has to recruit the same internal signal such a system is already [...]