Cuts, Switches, and Eight Extra Hairs

The 2025 Antibiotic Prophylaxis in Dermatologic Surgery (APDSAS) advisory statement simplifies clinical practice by restricting prophylaxis to mucosal or infected skin procedures, effectively removing previous requirements for groin or lower-extremity second-intent healing. Regarding atopic dermatitis, treatment persistence after advanced therapy failure varies by response type: primary non-responders often achieve better outcomes when switching to a JAK inhibitor, while secondary non-responders show higher persistence rates with alternative biologics. Furthermore, while retrospective data suggests morning administration of low-dose oral minoxidil for androgenic alopecia may improve hair density, these findings lack robust randomized evidence and likely reflect confounding variables rather than true circadian biological advantages. These updates provide practical, evidence-based guidance for managing common dermatological conditions, moving away from outdated prophylactic practices and refining therapeutic switching strategies for chronic inflammatory skin disease.