In this episode of Tank Talks, host Matt Cohen sits down with Anthony Mouchantaf, co-founder and CEO of Biossil, a biotech company on a mission to resurrect orphaned drugs using AI and a hedge fund–inspired operating model. Anthony takes us through his unconventional journey: from a law school student obsessed with Alexander Hamilton, to founding his first startup, Rthm (acquired), to investing at OMERS and RBC, and finally returning to the founder seat with Biossil.

They dive into the mindset shift required to leave a stable legal career for the uncertainty of startups, why Anthony views entrepreneurship as a “drug,” and how his time as an LP shaped his view of what separates great VCs from mediocre ones. Anthony opens up about the early days of Biossil, the “too cute” capital-efficient strategy, and how a serendipitous dinner intro to Founders Fund changed everything.

He also breaks down the real-world mechanics of acquiring off-the-shelf drugs, the brutal reality of biotech timelines, and why regulatory reform is the hidden bottleneck to AI-driven medicine. From the partnership with OpenAI to the company’s operating philosophy (hedging beta, maximizing catalyst density, and isolating alpha), Anthony offers a blueprint for building a resilient, mission-driven biotech for the AI era.

Whether you’re a founder, investor, or just someone curious about the intersection of AI and life sciences, this episode is packed with hard-earned wisdom on risk, identity, and the art of controlling what you can control.

From Law School to Startup Life (02:24)

* Growing up in Toronto as the child of immigrant parents, chasing constitutional law

* The Alexander Hamilton obsession that started in high school

* Teaching a course at U of T law without ever practicing

* How a late-night conversation at Massey College with co-founder Alex led to Rthm

What Founding Rthm Taught Him About Himself (06:14)

* Getting comfortable with structural uncertainty as almost “a drug”

* Why you can take the individual out of the startup, but never the startup out of the individual

* The itch that never fully goes away after founding something

From Founder to Investor: OMERS and RBCX (07:11)

* What separates great investors from destructive ones

* “Extremely hard to kill”: what he saw early in Matt and Ripple Ventures

* Why most VCs cluster around mediocrity, and what the outliers do differently

* The poker-chip analogy: how capital position shapes VC risk appetite

* Why good LPs need to “thumb the scale” for good VCs, just as good VCs do for founders

The Idea Behind Biossil (15:05)

* Reuniting with Alex, an MD-PhD, after years on separate paths

* The core problem: drug development should be recursive, but biotechs can’t afford to make it so

* Why promising drugs get stranded in “regulatory limbo” when the data is equivocal, not failed

* The insight: using technology to systematize what was historically a relationship-driven, human-scale rescue effort

Biossil 1.0 vs. the Bigger Vision (20:43)

* Launching in 2023 on a lean seed round with no capital to acquire drugs outright

* Getting “too cute” trying to solve the problem at a fraction of the necessary cost

* Why most VCs evaluate founders cross-sectionally instead of longitudinally

Hunting for Orphaned Drugs (26:03)

* Why data is a cost of admission in biotech, not a moat like in tech

* How Biossil structures deals to share economics with original rights holders

* Why inbound interest rarely meets their bar

Running Biossil Like an Operating Hedge Fund (30:50)

* Isolating alpha, or execution, from beta, or market and biotech cycle risk

* Why traditional biotech investing is “binary risk you can’t underwrite” without a portfolio

* Building resilience through catalyst density instead of just runway

* The “epsilon” factor: surviving long enough for unexplained outcomes to work in your favor

Building Lean with AI (34:12)

* Running a hyper-efficient, eight-person core team

* Why Biossil takes on regulatory and commercial risk, not manufacturing risk

* The pipeline today: $70M raised, 11 drugs, 5 open clinical trials across the US, Canada, and Europe

* What makes manufacturing the most underestimated cost in biotech

The Next 5-10 Years for Biossil (49:47)

* The long-term vision: an approved-drug pipeline, deeper trials, more disease areas

* Bringing new mechanisms of action to market as a category-defining goal

Advice to His Past Self (51:15)

* Why he’s hesitant to just tell people to “go do entrepreneurship”

* Motivation matters more than the identity of being a founder

* The Steve Jobs commencement speech that reframed how he thinks about risk

About Anthony Mouchantaf

Anthony Mouchantaf is the co-founder and CEO of Biossil, a biotech company that uses AI to systematically identify, acquire, and advance orphaned drugs left behind by failed clinical trials. With a background in law (U of T), startup founding (Rthm, acquired), and venture investing (OMERS, RBC), Anthony brings a rare blend of legal, financial, and operational discipline to the high-stakes world of drug development. Biossil is backed by Founders Fund and OpenAI, and is on a mission to turn industrial-scale drug resurrection into a new category of biotech innovation.

Connect with Anthony Mouchantaf: https://www.linkedin.com/in/anthony-mouchantaf-508442113/

Learn more about Biossil: https://www.biossil.co/

Connect with Matt Cohen on LinkedIn: https://ca.linkedin.com/in/matt-cohen1

Visit the Ripple Ventures website: https://www.rippleventures.com/

This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit tanktalks.substack.com

How Biossil is Rescuing Billion-Dollar Drugs Big Pharma Abandoned | Anthony Mouchantaf

Tank Talks By Ripple Ventures

How Biossil is Rescuing Billion-Dollar Drugs Big Pharma Abandoned | Anthony Mouchantaf