Alfredo Brown, Derek Brown and Andrew Erickson are breaking down the matchups, players and storylines that could define the opening weekend. The guys make their predictions for Bengals vs. Buccaneers, Saints vs. Lions, Ravens vs. Colts, Bills vs. Texans and Packers vs. Vikings while identifying the biggest X-factor in each matchup.

Which players could swing Week 1 for fantasy football managers? The crew discusses Chris Godwin, Chase Brown, Juwan Johnson, Mark Andrews, Dalton Kincaid, Kyler Murray, Marshawn Lloyd and more. Plus, Erickson predicts a monster performance from Jonathan Taylor against Baltimore, while D-Bro explains why Emeka Egbuka could be headed for a difficult opening week.

The show closes with the biggest things to watch across the NFL, including Trevor Lawrence and the Jacksonville Jaguars offense, the Washington Commanders offensive line and the new-look Chicago Bears offense with Caleb Williams. Most importantly, don't let one game wreck your fantasy football process: Week 1 creates massive overreactions, and those mistakes can create some of the best buy-low and sell-high opportunities of the season.

Timestamps: (May be off due to ads)

Intro - 0:00:00

DK Metcalf's Lost City of Antarctica - 0:01:46

Mahomes "Most Likely" Starts Week 1 - 0:03:03

Tua Talk - 0:04:05

J.K. Dobbins Listed As Starter - 0:05:18

Mason Taylor Gets Nod Over Kenyon Sadiq - 0:06:22

Polymarket - 0:08:25

Buccaneers vs. Bengals - 0:09:31

Lions vs Saints - 0:15:50

Colts vs Ravens - 0:20:06

Bills vs Texans - 0:25:51

Vikings vs. Packers - 0:30:47

Pristine Auction Giveaway - 0:36:25

Player Predictions - 0:37:06

Week One Thing To Watch - 0:41:48

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NFL Week 1 Predictions: Game Picks, X-Factors & Bold Fantasy Football Calls (Ep. 2181)

FantasyPros - Fantasy Football Podcast

NFL Week 1 Predictions: Game Picks, X-Factors & Bold Fantasy Football Calls (Ep. 2181)