With the Trump administration’s newest political persecution of Anthony Fauci and three years after our first lab-leak special, now seemed like a useful time to return to the topic. Fortunately, you do not have to rely on our knowledge of viruses, as we have somehow managed to convince the same three esteemed virologists, Eddie Holmes, Kristian Andersen and Michael Worobey, to come back for an update.

Mike, Kristian and Eddie return and offer us their read on where the scientific evidence on COVID’s origins stands in 2026. They take us through the main lines of evidence and the often overlooked role of the wildlife trade, explaining why the lab-leak story remains so appealing, and how their own assessments have shifted as more evidence has emerged. We also discuss the standard claim that the media suppressed the lab-leak narrative while noting that coverage across both alternative and mainstream outlets remains heavily skewed towards it (and almost entirely detached from the research literature).

Finally, we end on a characteristically positive note by discussing the Trump administration’s attacks on science and the ongoing campaigns against high-profile scientists and public health figures. Our guests describe their experience of committing the heinous offence of following the scientific evidence and arriving at conclusions that contradict the preferred views of polemical politicians and prominent media pundits.

In short, this episode is our modest attempt to drag the topic back towards the science, while also focusing on the price paid by the people who actually conduct the research and care about the evidence. We are not neutral when it comes to the ongoing attacks on science and scientists and do not pretend to be.

Links

Relevant research papers and reviews

Lab Leak Groundhog Day: COVID Origins in 2026 with Worobey, Andersen, and Holmes

Decoding the Gurus

Lab Leak Groundhog Day: COVID Origins in 2026 with Worobey, Andersen, and Holmes