Don't screw up your season from the jump! Join Joe Pisapia, Derek Brown and Andrew Erickson as they draft or pass on 12 early-round fantasy football draft picks for the 2025 NFL season.

Is San Francisco 49ers RB Christian McCaffrey worth the risk of a second-round pick? Is it pointless to select Kansas City Chiefs QB Patrick Mahomes again? Plus, can New Orleans Saints WR Chris Olave come back from a concussion-laced year?

The Pros send up a smoke signal on these polarizing prospects!

Timestamps: (May be off due to ads)

Introduction - 0:00:00
Christian McCaffrey (RB - SF) - 0:01:07
Jonathan Taylor (RB - IND) - 0:06:35
Draftkings Pick6 - 0:10:15
Tyreek Hill (WR - MIA) - 0:11:30
Breece Hall (RB - NYJ) - 0:15:33
Garrett Wilson (WR - NYJ) - 0:19:40
Rashee Rice (WR - KC) - 0:22:57
Microsoft Chasing Challenges - 0:27:22
Davante Adams (WR - LAR) - 0:29:34
Kenneth Walker (RB - SEA) - 0:33:58
Marvin Harrison Jr. (WR - ARI) - 0:39:27
Omarion Hampton (RB - LAC) - 0:44:39
Chris Olave (WR - NO) - 0:48:22
Patrick Mahomes (QB - KC) - 0:51:45
Outro - 0:56:09

Helpful Links:

DraftKings Pick6 – Download the DraftKings Pick6 app NOW on Google Play or the App Store and use code FANTASYPROS. This offer is for new customers to play $5, get $50 in Pick6 credits. Only on DraftKings Pick6. The crown is yours.

Gambling Problem? Call 1-800-GAMBLER. Help is available for problem gambling. Call 888-789-7777, or visit ccpg.org in Connecticut. Must be eighteen plus, age and eligibility restrictions vary by jurisdiction. Pick6 not available everywhere, including New York and Ontario. Void where prohibited. One per new customer. Bonus awarded as non-withdrawable Pick6 Credits that expire in thirty days. Limited time offer. See terms at https://pick6.draftkings.com/promos.

⁠⁠⁠Microsoft AI⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ -⁠⁠⁠ Microsoft’s AI solutions empower you to take bold steps and make informed decisions, sparking new ideas to help drive your business forward. With Microsoft as your trusted partner, you can navigate your journey with confidence, finding innovative solutions and reaching new possibilities. Visit ⁠⁠⁠⁠⁠microsoft.com/challengers⁠⁠⁠⁠⁠ to learn more.

Dynasty Rookie Draft Simulator - Our Dynasty Rookie Draft Simulator lets you complete a mock in minutes with no waiting between picks! Customize your league settings to match your league’s exact format. Premium subscribers can test trade scenarios by mocking with their traded draft picks. Prepare for rookie drafts AND dynasty startup drafts in one place! Use the Dynasty Rookie Draft Simulator to dominate your rookie draft today at fantasypros.com/simulator!

Discord - Join our FantasyPros Discord Community! Chat with other fans and get access to exclusive AMAs that wind up on our podcast feed. Come get your questions answered and BE ON THE SHOW at fantasypros.com/chat

Leave a Review – If you enjoy our show and find our insight to be valuable, we’d love to hear from you! Your reviews fuel our passion and help us tailor content specifically for YOU. Head to Apple Podcasts, Spotify, or wherever else you get your podcasts and leave an honest review. Let’s make this show the ultimate destination for fantasy football enthusiasts like us. Thank you for watching and for showing your support – https://fantasypros.com/review/

BettingPros Podcast – For advice on the best picks and props across both the NFL and college football each and every week, check out the BettingPros Podcast at bettingpros.com/podcast, our BettingPros YouTube channel at youtube.com/bettingpros, or wherever you listen to podcasts.

See omnystudio.com/listener for privacy information.

MAKE OR BREAK | Will These 12 Players Lead to Victory or Defeat? (Ep. 1569)

FantasyPros - Fantasy Football Podcast

MAKE OR BREAK | Will These 12 Players Lead to Victory or Defeat? (Ep. 1569)