Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives

Biohub accelerates scientific discovery by integrating frontier AI with advanced biological research to create hierarchical world models of human biology. By shifting from traditional, siloed research to open-source, collaborative tool development, the initiative empowers the global scientific community to address the full spectrum of human disease. Key efforts include protein structure prediction, such as the ESMFold model, and cellular engineering to map complex biological systems. This approach moves beyond reductionist science toward an engineering-based understanding of living cells, enabling researchers to predict off-target effects and design personalized therapeutics. By prioritizing open data and shared methodologies, the initiative overcomes the limitations of traditional drug development, aiming to cure, prevent, or manage all diseases by the end of the century through a decentralized, high-impact scientific ecosystem.