Let's the betting begin! With just over 100 days remaining until kickoff of the 2026 NFL regular season, betting expert Chad Millman and professional gambler Simon Hunter examine the betting lines across all 16 games on the NFL Week 1 slate.

Together we hear about the Cleveland Browns as big underdogs against the Jacksonville Jaguars, an Australian divisional game between the San Francisco 49ers and Los Angeles Rams and a matchup of two AFC playoff hopefuls in Buffalo Bills at Houston Texans. We also get a Super Bowl rematch between the New England Patriots and Seattle Seahawks, and a garbage can affair between the lowly New York Jets and Tennessee Titans. Will Patrick Mahomes return to Kansas City in time to host the Denver Broncos? Will Jaxson Dart put it all together for the New York Giants against the Dallas Cowboys? We get all of our duo's picks and predictions for these mid-September matchups, including their first Big Balls Bet of the Week of the 2026 NFL season! #Volume

0:03:00 - START

0:09:00 - PATRIOTS VS. SEAHAWKS

0:12:00 - 49ERS VS. RAMS

0:14:00 - BROWNS VS. JAGUARS

0:17:30 - JETS VS. TITANS

0:19:30 - RAVENS VS. COLTS

0:25:15 - BILLS VS. TEXANS

0:28:00 - BUCS VS. BENGALS

0:31:15 - BEARS VS. PANTHERS

0:42:00 - FALCONS VS. STEELERS

0:44:30 - SAINTS VS. LIONS

0:48:30 - CARDINALS VS. CHARGERS

0:50:00 - DOLPHINS VS. RAIDERS

0:52:00 - PACKERS VS. DOLPHINS

0:54:30 - COMMANDERS VS. EAGLES

0:57:00 - COWBOYS VS. GIANTS

1:00:00 - BRONCOS VS. CHIEFS

-- All lines provided by Hard Rock Bet

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NFL WEEK 1 BETTING LINES - 2026 Regular Season Openers

Sharp or Square

NFL WEEK 1 BETTING LINES - 2026 Regular Season Openers