Mixing lidocaine, ropivacaine, and bicarbonate is routine in many hospitals, but is it actually safe? In this episode, we discuss the main findings from a 2026 article by Gasteiger et al. (Anesthesiology), which questions the stability, efficacy, and safety of common local anesthetic mixtures. From crystal formation to reduced block performance, we explore why combining drugs may do more harm than good, and how to rethink this everyday practice.

Read more about this on NYSORA.com.

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Mixing Local Anesthetics: Smart Shortcut or Hidden Risk?

Anesthesia Updates

Mixing Local Anesthetics: Smart Shortcut or Hidden Risk?