What if we could make the brain see-through?

It sounds like science fiction, but it could revolutionize how we study the brain.

Today on the show, we're talking with Guosong Hong, a faculty scholar here at the Wu Tsai Neurosciences Institute who has a unique reputation for developing creative techniques that literally shed light on the brain—from using fluorescent nanomaterials and focused ultrasound to create a virtual flashlight inside the skull, to discovering a common food dye that temporarily makes skin, muscle, and even parts of the brain transparent.

Now, Guosong and colleagues are taking this work to the next level through a Wu Tsai Neuro Big Ideas grant, genetically engineering mice to have see-through brains from birth.

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Big Ideas: How see-through brains could transform neuroscience | Guosong Hong

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Big Ideas: How see-through brains could transform neuroscience | Guosong Hong