Episode 018: Heme/Onc Emergencies, Pt. 7: TTP

The podcast addresses thrombotic thrombocytopenic purpura (TTP), a dangerous hematological condition marked by microvascular blood clots and thrombocytopenia. The discussion demystifies TTP, emphasizing its high mortality rate if untreated and the importance of early recognition. Speakers highlight the classic pentad of symptoms: fever, anemia, thrombocytopenia, kidney issues, and neurological changes. They detail the role of ADAMTS-13, an enzyme deficiency that leads to excessive von Willebrand factor multimers activating platelets. The podcast underscores the significance of avoiding prophylactic platelet transfusions and initiating prompt treatment, such as plasma exchange and steroids, while awaiting ADAMTS-13 test results. The presenters also introduce the PLASMIC score as a tool to assess the probability of TTP and guide treatment decisions.