Today, I'm joined by the extraordinary Dr. Natalie Yivgi-Ohana, a pioneering scientist whose passion for mitochondria unlocks new frontiers in longevity medicine. Our conversation truly blew my mind—Dr. Yivgi-Ohana brings decades of expertise to demystify these tiny, ancient powerhouses that fuel every cell in our bodies, impact our hormones, drive immunity, and, as it turns out, play a central role in how we age.

Episode Timestamps:

Welcome to the Longevity Podcast and today's focus on mitochondria ... 00:00:00

Maternal inheritance and critical functions of mitochondria ... 00:05:56

Mitochondria as energy producers and hormone regulators ... 00:07:03

Aha moments: mitochondria control life, death, and disease ... 00:08:55

Endosymbiotic theory: how mitochondria originated ... 00:10:19

Chronic disease, aging, and the connection to mitochondria ... 00:16:10

Substrate fuels: carbs, fats, and importance of metabolic flexibility ... 00:20:18

Mitochondria's control over immune system and signaling ... 00:26:39

Mitochondrial transfer: how cells share organelle "powerhouses" ... 00:32:42

Groundbreaking therapy: transplanting mitochondria for rare diseases ... 00:36:40

Expanding mitochondrial therapies to age-related diseases ... 00:42:57

Aging in women: hormones, mitochondria, and inflection points ... 00:51:00

Stem cell exhaustion and cellular renewal ... 00:52:24

Biomarkers: ways to measure mitochondrial health ... 01:03:11

Supplements, lifestyle, and emotional health for mitochondria ... 01:15:47

Medication choices and minimizing mitochondrial toxicity ... 01:24:04

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