#109 How To Boost NAD Levels To Fight Inflammation, Improve Recovery, and Slow Aging | Dr. Charles Brenner | FoundMyFitness

The podcast explores the critical role of NAD, a molecule essential for cellular energy, DNA repair, and gene regulation, with Dr. Charles Brenner, a biochemist renowned for discovering nicotinamide riboside (NR), a potent NAD precursor. The discussion addresses how conditions like obesity, inflammation, and sleep deprivation impact NAD levels, highlighting NR's anti-inflammatory benefits demonstrated in clinical trials. Practical advice includes aligning NR supplementation with circadian rhythms by taking it in the morning. The conversation also dispels myths around intravenous NAD therapies versus oral supplementation, emphasizing NR's superior bioavailability and clinical efficacy. Additionally, the influence of the gut microbiome on NAD metabolism and the potential benefits of NR for fertility and developmental outcomes are examined.

Outlines

Part 1: NAD Basics, Biology, and Aging

Part 2: Stressors and NAD Depletion

Part 3: Clinical Evidence and Lifestyle Interventions

Part 4: Exercise, Recovery, and Pregnancy

Part 5: Comparing Precursors and Delivery Methods

Part 6: Disease Prevention and Future Outlook

Part 7: Safety, Dosing, and Sourcing

Part 8: Deep Dive: Discovery and Biochemistry

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#109 How To Boost NAD Levels To Fight Inflammation, Improve Recovery, and Slow Aging | Dr. Charles Brenner

FoundMyFitness

Part 1: NAD Basics, Biology, and Aging

00:00NAD's Crucial Role in Cellular Energy, DNA Repair, and Immunity

NAD's Crucial Role in Cellular Energy, DNA Repair, and Immunity

01:25Supplement Timing, Fertility Benefits, and Gut Microbiome Influence on NAD

Supplement Timing, Fertility Benefits, and Gut Microbiome Influence on NAD

04:40NAD Levels, Aging, and the Importance of Tissue-Specific Analysis

NAD Levels, Aging, and the Importance of Tissue-Specific Analysis

08:02Disease States, Inflammation, and the NAD System

Disease States, Inflammation, and the NAD System

Part 2: Stressors and NAD Depletion

10:17Coronavirus Infection and the Activation of PARP Superfamily

Coronavirus Infection and the Activation of PARP Superfamily

13:32Diet, NAD Precursors, and Tissue-Specific NAD Declines

Diet, NAD Precursors, and Tissue-Specific NAD Declines

17:00Obesity, Insulin Resistance, and Sleep Deprivation's Impact on the NAD System

Obesity, Insulin Resistance, and Sleep Deprivation's Impact on the NAD System

18:33Human Data on Obesity, Sleep Disturbance, and the NAD System

Human Data on Obesity, Sleep Disturbance, and the NAD System

Part 3: Clinical Evidence and Lifestyle Interventions

20:32Chronic Inflammation and the Anti-Inflammatory Effects of Nicotinamide Riboside

Chronic Inflammation and the Anti-Inflammatory Effects of Nicotinamide Riboside

25:17Lifestyle Changes for Supporting NAD: Addressing Inflammation and Individualized Recommendations

Lifestyle Changes for Supporting NAD: Addressing Inflammation and Individualized Recommendations

27:34The Importance of Movement and the Limitations of Blood NAD Measurements

The Importance of Movement and the Limitations of Blood NAD Measurements

29:06Nicotinamide Riboside and Cognitive Function Improvements in Long COVID Patients

Nicotinamide Riboside and Cognitive Function Improvements in Long COVID Patients

Part 4: Exercise, Recovery, and Pregnancy

31:35NAD Blood Level Measurements and Supplementation

NAD Blood Level Measurements and Supplementation

33:45Exercise and NAD: Supporting Systems and Gene Expression

Exercise and NAD: Supporting Systems and Gene Expression

36:39NAD's Role in Exercise Recovery and the Effects of Acute Sleep Loss

NAD's Role in Exercise Recovery and the Effects of Acute Sleep Loss

39:20Nicotinamide Riboside Supplementation During Pregnancy and Offspring Health

Nicotinamide Riboside Supplementation During Pregnancy and Offspring Health

44:24Safety of Nicotinamide Riboside During Pregnancy and Fertility Benefits

Safety of Nicotinamide Riboside During Pregnancy and Fertility Benefits

Part 5: Comparing Precursors and Delivery Methods

47:53Strategies for Mitigating Circadian Misalignment and the Timing of Nicotinamide Riboside

Strategies for Mitigating Circadian Misalignment and the Timing of Nicotinamide Riboside

51:20Why Supplement with a Precursor Instead of NAD Directly?

Why Supplement with a Precursor Instead of NAD Directly?

54:59Nicotinamide Riboside vs. Nicotinamide Mononucleotide and the Safety of Nicotinamide

Nicotinamide Riboside vs. Nicotinamide Mononucleotide and the Safety of Nicotinamide

57:02NAD IV Drips and the Superiority of Oral Nicotinamide Riboside

NAD IV Drips and the Superiority of Oral Nicotinamide Riboside

1:00:33Oral NAD Supplements and the Questionable Purity of NMN Products

Oral NAD Supplements and the Questionable Purity of NMN Products

1:02:36Why NMN is Converted Back to NR Before Entering Cells

Why NMN is Converted Back to NR Before Entering Cells

1:05:35The Gut Microbiome's Role in Converting NR and NMN into NAD

The Gut Microbiome's Role in Converting NR and NMN into NAD

Part 6: Disease Prevention and Future Outlook

1:08:16Nicotinamide Riboside and Immune-Related Benefits

Nicotinamide Riboside and Immune-Related Benefits

1:11:24Peripheral Artery Disease and the Promise of Nicotinamide Riboside

Peripheral Artery Disease and the Promise of Nicotinamide Riboside

1:14:31Neurodegenerative Disease, Liver Disease, and the Challenges of Clinical Trials

Neurodegenerative Disease, Liver Disease, and the Challenges of Clinical Trials

1:17:41Hepatic Fat Reduction with Nicotinamide Riboside and the Importance of Randomization

Hepatic Fat Reduction with Nicotinamide Riboside and the Importance of Randomization

1:21:21The Best Argument for Adding Nicotinamide Riboside to a Healthy Routine

The Best Argument for Adding Nicotinamide Riboside to a Healthy Routine

Part 7: Safety, Dosing, and Sourcing

1:22:31Dosing of Nicotinamide Riboside and Safety Considerations

Dosing of Nicotinamide Riboside and Safety Considerations

1:24:52Stacking Nicotinamide Riboside with Other Supplements

Stacking Nicotinamide Riboside with Other Supplements

1:26:33Sourcing and Third-Party Testing for Supplements

Sourcing and Third-Party Testing for Supplements

1:28:43Cancer Risk and Nicotinamide Riboside

Cancer Risk and Nicotinamide Riboside

1:31:40Animal Studies on Cancer and NAD

Animal Studies on Cancer and NAD

1:33:42The Worth of Supplementing with Nicotinamide Riboside

The Worth of Supplementing with Nicotinamide Riboside

Part 8: Deep Dive: Discovery and Biochemistry