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Lynne Chou O’Keefe is the Founder and Managing Partner of Define Ventures, one of the largest early-stage health tech investment firms, with $800 million in assets under management.

With deep experience across digital health, venture capital, and frontline healthcare systems, Lynne brings a clear-eyed view of why the industry is changing now and where AI can make a meaningful difference.

She is widely recognized for her work backing companies that rethink access, outcomes, and patient experience, and is a trusted voice on how technology, ethics, and human judgment must come together to move healthcare forward.

In this conversation, we discuss:

Why healthcare still runs on fragmented systems and what that means for where AI can truly move the needle.
How the shift from fee-for-service to value-based care changes incentives and pushes the system toward prevention over volume.
Why patients now expect healthcare to work like transportation or food delivery, and how that expectation reshapes care delivery.
The three phases of AI in healthcare, from administrative efficiency to clinical workflow support and, eventually, clinical decision-making.
Where the ethical boundary sits today between AI-assisted care and AI-led decisions, especially when access to care is limited.
Why the future of healthcare is hybrid by design, with AI augmenting clinicians rather than replacing human judgment.

Resources:

375: How AI Is Changing Healthtech Investing, According to Define Ventures’ Lynne Chou O’Keefe

AI and the Future of Work: Artificial Intelligence in the Workplace, Business, Ethics, HR, and IT for AI Enthusiasts, Leaders and Academics

375: How AI Is Changing Healthtech Investing, According to Define Ventures’ Lynne Chou O’Keefe