NEJM This Week — January 1, 2026

This week's NEJM podcast covers several medical topics, including new treatments for EGFR-mutated lung cancer, a brain-penetrant enzyme therapy for mucopolysaccharidosis 2 (MPS2), and dual targeting of extramedullary myeloma. It also reviews cardiogenic shock and presents a challenging diagnostic case of a young woman with recurrent illness, ultimately diagnosed with Common Variable Immunodeficiency (CVID). Additionally, the podcast explores perspectives on the corporatization of ambulatory care, concerns about evidence-based vaccine policy at the FDA, the use of estimands in clinical trials, and a clinician's perspective on dealing with grief. Finally, it presents clinical images related to osteogenesis imperfecta, congenital Zika syndrome, and tick-related skin reactions.