06 Nov 2025
40m

Essentials: Erasing Fears & Traumas Using Modern Neuroscience

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Huberman Lab

In this episode of Huberman Lab Essentials, Andrew Huberman discusses the neuroscience of fear, trauma, and post-traumatic stress disorders. He explains the biology of fear, including the cells, circuits, and chemicals involved in the fear response, and how fear can turn into trauma. He also covers the biology of how fear is unlearned or extinguished, emphasizing the importance of replacing fears with positive experiences. Huberman delves into the autonomic nervous system, the HPA axis, and the role of the amygdala in the threat reflex. He also discusses various therapies, including behavioral therapies like prolonged exposure therapy, cognitive processing therapy, and cognitive behavioral therapy, as well as drug treatments like ketamine-assisted and MDMA-assisted psychotherapy. The episode also touches on lifestyle and supplementation factors, such as saffron and inositol, that can impact fear and trauma.

Outlines

Part 1: Foundations of Fear and Trauma

Part 2: Undoing Fear and Trauma

Part 3: Recalibration and Lifestyle

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