Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

In this episode of Huberman Lab Essentials, Andrew Huberman interviews Dr. David Sinclair about aging, longevity, and actionable protocols to increase lifespan. They discuss the definition of aging as a disease, the role of the epigenome, and the loss of information due to entropy. Sinclair emphasizes the importance of lifestyle choices, such as fasting and exercise, in modulating the epigenome and activating longevity genes like sirtuins. They delve into the mechanisms by which blood sugar, insulin, and amino acids like leucine affect these pathways. Sinclair shares his personal protocol, which includes intermittent fasting, NMN supplementation, and exercise, to promote cellular defense and slow down the aging process, highlighting the significance of tracking blood sugar levels, inflammation markers like CRP, and personalizing health interventions based on individual needs and responses.