76: Pièce de (Gram-negative) Resistance, Part 1: AmpC, ESBL

This episode of Febrile, a podcast about infectious diseases, features a discussion on resistant Gram-negatives, specifically Enterobacterales, ESBLs, AmpC organisms, and CREs. The hosts, along with guest expert Dr. Pranita Tamma, delve into reading susceptibility patterns, antibiotic choices, and the implications of the updated IDSA guidance on antimicrobial-resistant Gram-negative infections. Through case studies, they explore treatment options, the role of cefepime and carbapenems, and the challenges posed by organisms like Klebsiella aerogenes and Morganella morganii. The episode also addresses the complexities of AmpC production and the limitations of older acronyms used to classify these organisms, providing insights into current approaches and evolving data in antimicrobial stewardship.