IBCC Episode 16 - Immune Checkpoint Inhibitors

In this episode of The Internet Book of Critical Care Podcast, Josh and Adam delve into the complexities of checkpoint inhibitor toxicity, a growing concern in cancer treatment. They explain how these drugs amplify the immune response against tumors by reducing inhibition on T-cells, but can inadvertently cause immune-related adverse events mimicking autoimmune diseases and affecting various organ systems. The discussion covers the core principles of checkpoint inhibitor toxicity, including the diverse clinical presentations, the challenging differential diagnoses, and the importance of considering alternative diagnoses. They explore specific organ involvement such as cardiac issues, pneumonitis, colitis, hepatitis, nephritis, endocrinopathies, neurological problems, hematologic issues, and dermatological manifestations, providing insights into evaluation and treatment strategies, including the use of steroids and other immunosuppressive agents.