NEJM This Week — September 18, 2025

This New England Journal of Medicine podcast episode from September 18th, 2025, covers a range of medical topics. It includes discussions on low-dose aspirin for PI3K-altered colorectal cancer, the effectiveness of oral orforaglupron for type 2 diabetes, and oral semaglutide for obesity. It also examines proportional assist ventilation for minimizing mechanical ventilation duration, tumor lysis syndrome, and a case report of a girl with chest pain and bone and liver lesions. Additionally, the podcast addresses integrating pharmacotherapy into tobacco control, protecting Medicaid enrollees with chronic conditions, and the ongoing debate surrounding ultra-processed foods, concluding with images in clinical medicine and contact information for feedback.