#359 ‒ How metabolic and immune system dysfunction drive the aging process, the role of NAD, promising interventions, aging clocks, and more | Eric Verdin, M.D.

In this episode of The Drive, Peter Attia interviews Dr. Eric Verdin, president and CEO of the Buck Institute for Research on Aging, about the science of longevity. They discuss the roles of immunology and metabolism in aging, including the impact of chronic inflammation, oxidative stress, and fuel utilization. They delve into the complexities of NAD levels, sirtuins, and the potential benefits and drawbacks of supplements like NMN and NR, as well as the role of CD38. The conversation also covers potential interventions like rapamycin, growth hormone, and GLP-1 agonists, and the challenges of measuring biological age using epigenetic clocks and proteomic tests. They explore the importance of exercise and lifestyle factors in promoting healthy aging and the need for caution when interpreting results from commercially available aging tests.