TWiST 500 interviews with Cortical Labs, Turing, AND Mercor | E2159

This episode of This Week in Startups, hosted by Lon Harris and Alex Wilhelm, features three interviews from the Twist 500. The initial discussion revolves around Sam Altman's comments on GPT-5 and the broader implications of AI advancements, including potential misuse and the hype surrounding new models. The hosts discuss the anticipation for OpenAI's OpenWeights model and GPT-5's expected release. The episode then transitions to interviews with Hon Weng Chong, CEO of Cortical Labs, discussing hybrid biologic and digital computers; Jonathan Siddarth, CEO of Turing, about LLM evaluation; and Brendan Foody, CEO of Mercor, about using AI to improve job matching. Each interview explores the company's vision, technology, and market applications.