28 Jul 2025
2h 26m

Male vs. Female Brain Differences & How They Arise From Genes & Hormones | Dr. Nirao Shah

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Huberman Lab

In this episode of the Huberman Lab Podcast, Andrew Huberman interviews Dr. Nirao Shah about the biology of sex differences in the brain and body. The discussion covers the impact of hormones like testosterone and estrogen on brain development, the role of the SRY gene in determining sex, and the neural circuits controlling sex and aggressive behavior. They explore anatomical and functional differences between male and female brains, the influence of hormones on behavior, and the complexities of gender identity. They also touch on the ethical considerations of hormone administration and gender-affirming care, and the potential for drug development targeting libido and sexual function.

Outlines

Part 1: Introduction and Hormonal Influence

Part 2: Brain Structure, Function, and Historical Context

Part 3: Neural Circuits and Sexual Behavior

Part 4: Libido, Drug Targets, and Brain Changes

Part 5: Conclusion

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