Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy

In this episode of the Huberman Lab Podcast, Andrew Huberman interviews Dr. Chris McCurdy about the plant-derived compound kratom, its effects on the nervous system, and its potential for addiction. Dr. McCurdy explains kratom's traditional use, its interaction with the opioid system, and the critical differences between the kratom leaf and the derivatives and isolates sold in the U.S. The discussion covers kratom's effects at different doses, its potential as a stimulant, painkiller, and its ability to aid in transitioning off opioid drugs, while also addressing the potential harms, especially in young people and those without prior opioid addiction. The conversation broadens to include other plant alkaloids with medicinal properties, such as those in cocoa and the history of soft drinks as pharmacological tools.