YouTube26 May 2025
1h 52m

Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo

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Andrew Huberman

Human genetics and behavior interact to drive rapid evolutionary adaptations, challenging the notion that genetic traits are entirely predetermined. Dr. Melissa Ilardo, a biomedical informatics professor, explains how environmental pressures, such as the need for breath-hold diving among the Bajo sea nomads, trigger physiological changes like spleen contraction and increased red blood cell counts. These adaptations, often facilitated by higher thyroid hormone levels, demonstrate how specific behaviors influence gene expression and survival within generations. Beyond physical traits, mate selection functions as a biological proxy for immune system diversity, with individuals naturally preferring partners with distinct histocompatibility complexes to enhance offspring resilience. These findings reveal that human evolution remains an active, ongoing process, shaped by both cultural practices and the fundamental biological drive to secure resources and optimize physiological performance in changing environments.

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