War, invasion, civil unrest… or plague? Could a series of deadly pandemics have helped bring down the mighty Roman Empire?

In the third episode of our Fall of Rome mini-series, Tristan Hughes is joined by Professor Kyle Harper – author of The Fate of Rome – to explore how disease and climate change may have crippled this superpower of the ancient world. From the Antonine Plague of the 160s AD to the terrifying Cyprianic Plague that ravaged Carthage and beyond, this episode investigates how pandemics devastated populations, shattered economies, and reshaped imperial policy.

Join us as we uncover the dark side of Roman history – a world of weeping sores, mass graves, and myths of divine vengeance – and ask the big question: Could nature have delivered the final blow to the Roman Empire?

MORE:

Lessons from the Antonine Plague:

https://open.spotify.com/episode/1wsEtmlqkwqLbQlgZ8TW1L

Plague of Athens:

https://open.spotify.com/episode/1al8GluN7NBvuzXayHe74F

Presented by Tristan Hughes. Audio editor is Aidan Lonergan, the producer is Joseph Knight. The senior producer is Anne-Marie Luff.

All music courtesy of Epidemic Sounds

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Did Plague Destroy the Roman Empire?

The Ancients

Did Plague Destroy the Roman Empire?