This episode is the second of a two-part series on Primeadine: a new healthy aging Spermidine supplement that is already getting rave reviews. Spermidine is a potent polyamine, known for inducing autophagy or cellular renewal. As we age, our bodies are getting slower and slower in the production of spermidine leaving us more reliant on exogenous sources be they food or supplementation.

Supplementation with spermidine in humans has been shown to support cognition and heart health, balance hormones and improve hair growth and fullness (including eyelashes), strengthening nails. Spermidine also positively impacts five of the nine hallmarks of aging including: misfolded proteins (impaired proteostasis), epigenetic changes, mitochondrial dysfunction, stem cell dysfunction, impaired cellular communication.

Amy Lamotte is a fellow biohacker and in this episode, she shares her amazing hacks and simple and effective techniques that anyone can follow. We talk about the benefits of Spermidine, its mechanisms, and how it induces autophagy. She also shares about how she hacked her autoimmune disease, treating it and reversing it herself through diet, supplementation and testing. You shouldn’t miss this episode. Listen in!

Meet this week’s guest:

Amy Lamotte is the Managing Director of Vallotte Nutrigenomics Limited in Hong Kong. She is a clinical nutritionist and researcher specializing in personalized nutrition, nutritional biochemistry, nutrigenetics, and nutrigenomics. Other areas of interest include anti-aging, circadian biology, and the microbiome. She has a Master’s of Science in Human Nutrition (summa cum laude) from the University of Bridgeport and a J.D. from Yale Law School.

Key Highlights:

[13:38] The mechanisms of Spermidine

[06:05] What is autophagy and why is it important?

[19:41] The influence of Spermidine levels in different age groups

[22:12] Different factors and theories in dysregulation of spermidine

[25:07] Diet has a big effect on preventive healthcare

[26:50] The two great powerful combo - diet and supplements

[31:35] What are the best supplements to take and not to take?

[34:53] There are two types in human studies: epidemiological studies and clinical trials

[38:44] The human clinical study of spermidine and the after results

Linkage:

Oxford Healthspan (Use promo code BIONAT15 to save 15% off your order.)

Connect with Amy:

Instagram: @amylamotte

Linkedin: https://www.linkedin.com/in/amy-valley-lamotte-501676111/

Website: https://www.amylamotte.com/

Promo code: Bionat15 for 15% off for your full order

To Try Primeadine: Primeadine.com

REFERENCES FROM PODCAST INTERVIEW:

REVIEW ON DIETARY & GUT MICROBIOTA POLYAMINES

Ramos-Molina, B., Queipo-Ortuño, M. I., Lambertos, A., Tinahones, F. J., & Peñafiel, R. (2019). Dietary and gut microbiota polyamines in obesity-and age-related diseases. Frontiers in nutrition, 6, 24.

EPIDEMIOLOGICAL STUDIES RE SPERMIDINE/POLYAMINES

Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., ... & Madeo, F. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature medicine, 22(12), 1428-1438.

Kiechl, S., Pechlaner, R., Willeit, P., Notdurfter, M., Paulweber, B., Willeit, K., ... & Willeit, J. (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based study. The American journal of clinical nutrition, 108(2), 371-380.

Pucciarelli, S., Moreschini, B., Micozzi, D., De Fronzo, G. S., Carpi, F. M., Polzonetti, V., ... & Napolioni, V. (2012). Spermidine and spermine are enriched in whole blood of nona/centenarians. Rejuvenation research, 15(6), 590-595

Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A. (2020). Spermidine intake is associated with cortical thickness and hippocampal volume in older adults. NeuroImage, 221, 117132.

Soda, K., Kano, Y., & Chiba, F. (2012). Food Polyamine and Cardiovascular Disease-An Epidemiological Study. Global journal of health science, 4(6), 170.

HUMAN TRIALS RE SPERMIDINE

Pekar, T., Bruckner, K., Pauschenwein-Frantsich, S., Gschaider, A., Oppliger, M., Willesberger, J., ... & Jarisch, R. (2020). The positive effect of spermidine in older adults suffering from dementia. Wiener klinische Wochenschrift, 1-8.

Schwarz, C., Stekovic, S., Wirth, M., Benson, G., Royer, P., Sigrist, S. J., ... & Flöel, A. (2018). Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging (Albany NY), 10(1), 19.

Wirth, M., Benson, G., Schwarz, C., Köbe, T., Grittner, U., Schmitz, D., ... & Flöel, A. (2018). The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex, 109, 181-188.

IN VIVO STUDY RE MICROBIAL SPERMIDINE PRODUCTION & BONE

Chevalier, C., Kieser, S., Çolakoğlu, M., Hadadi, N., Brun, J., Rigo, D., ... & Trajkovski, M. (2020). Warmth prevents bone loss through the gut microbiota. Cell metabolism, 32(4), 575- 590.

POLYAMINES/SPERMIDINE IN FOOD

Handa, A. K., Fatima, T., & Mattoo, A. K. (2018). Polyamines: bio-molecules with diverse functions in plant and human health and disease. Frontiers in chemistry, 6, 10.

Kandasamy, S., Yoo, J., Yun, J., Kang, H. B., Seol, K. H., & Ham, J. S. (2021). Quantitative Analysis of Biogenic Amines in Different Cheese Varieties Obtained from the Korean Domestic and Retail Markets. Metabolites, 11(1), 31.

Okamoto, A., Sugi, E., Koizumi, Y., Yanagida, F., & Udaka, S. (1997). Polyamine content of ordinary foodstuffs and various fermented foods. Bioscience, biotechnology, and biochemistry, 61(9), 1582-1584.

SEX DIFFERENCES RE EXERCISE & AUTOPHAGY INDUCTION

Escobar, K. A., Welch, A. M., Wells, A., Fennel, Z., Nava, R., Li, Z., ... & Mermier, C. M. (2020). Autophagy response to acute high-intensity interval training and moderate-intensity continuous training is dissimilar in skeletal muscle and peripheral blood mononuclear cells and is influenced by sex. Human Nutrition & Metabolism, 200118.

Amy Lamotte on the Anti aging Effects of Spermidine Part 2

LONGEVITY with Nathalie Niddam

Amy Lamotte on the Anti aging Effects of Spermidine Part 2