#247 SPEP It Up: MGUS, Myeloma, and Immunology, Oh My!

In this episode of The Curbsiders, Dr. Jorge Castillo joins the hosts to discuss the diagnosis and management of monoclonal gammopathies, including MGUS, multiple myeloma, Waldenstrom's macroglobulinemia, and amyloidosis. The discussion covers how to interpret serum and urine protein electrophoresis, immunofixation, and free light chain assays. Dr. Castillo explains the key differences between these conditions, focusing on clinical presentation, diagnostic workup, and treatment approaches, while emphasizing the importance of considering these disorders in patients with anemia, kidney disease, neuropathy, or hypercalcemia. He also highlights the significance of patient participation in research to advance the understanding and treatment of these conditions.