Alan Green MD: Rapamycin for Longevity in Clinical Practice

Rapamycin serves as a powerful tool for longevity by modulating the mTOR pathway, which acts as a master regulator of cellular aging. By utilizing intermittent dosing—typically once weekly—practitioners can inhibit mTOR1 to achieve anti-aging benefits while sparing mTOR2, thereby avoiding the adverse side effects seen in continuous transplant-related protocols. Dr. Alan Green, a board-certified pathologist with extensive clinical experience, reports significant patient improvements in cardiac function, insulin sensitivity, and systemic inflammation. Beyond pharmacological intervention, maintaining a low-methionine diet and monitoring metabolic markers like the HOMA-IR score and waist-to-height ratio are essential for managing age-related decline. This approach addresses the underlying inflammatory processes driving conditions ranging from cardiomyopathy to neurodegeneration, offering a proactive strategy for extending healthspan rather than merely treating symptoms.