Gordan Lauc PhD: Glycans- The Next Biological Longevity Clock?

Glycans represent a critical biological layer of information, often described as the third revolution in evolution following RNA and proteins. Unlike glycation, which signifies chemical damage from excess glucose, glycosylation is a highly regulated enzymatic process that dictates protein function. Specifically, glycans attached to immunoglobulin G antibodies serve as primary regulators of inflammation, with their composition shifting significantly during aging. A high "glycan age" serves as a reliable, actionable biomarker for chronic inflammation and future disease risk, including cardiovascular issues. Unlike static genetic markers, glycan profiles respond dynamically to lifestyle modifications such as weight management and hormone optimization. By monitoring these molecular changes, individuals can identify early signs of systemic dysfunction and implement preventative strategies years before clinical symptoms of chronic disease manifest.