Scott Sherr MD: Hyperbaric Oxygen Therapy and Alzheimer’s Disease

Hyperbaric oxygen therapy (HBOT) serves as a potent, synergistic tool for treating Alzheimer’s disease and promoting neurological health by leveraging increased atmospheric pressure to saturate blood plasma with oxygen. This process bypasses traditional red blood cell limitations, effectively reducing neuroinflammation, stimulating angiogenesis, and enhancing mitochondrial biogenesis. Beyond acute trauma recovery, HBOT functions as a long-term regenerative strategy that can downregulate inflammatory cytokines and support cellular repair. However, optimal clinical outcomes for chronic cognitive decline rely on an integrative framework—Health Optimization Medicine—which addresses foundational nutrient, gut, and hormonal imbalances before or alongside hyperbaric sessions. By combining these systemic optimizations with targeted pressure protocols, clinicians can effectively address the microvascular ischemic changes and cellular dysfunction characteristic of Alzheimer’s, offering a pathway to improved brain metabolism and cognitive function.