#09 - David Sabatini, M.D., Ph.D.: rapamycin and the discovery of mTOR — the nexus of aging and longevity?

This podcast episode features David Sabatini, a distinguished scientist, who discusses his groundbreaking research on mTOR and rapamycin, focusing on the complexities of mTOR modulation and its implications for health and longevity. Sabatini emphasizes the role of persistence and serendipity in scientific discovery, illustrating the evolution of mTOR research and its critical functions in cellular processes, particularly autophagy. He advocates for a nuanced understanding of mTOR targeting, advocating for upstream regulators to balance efficacy with safety, while laying out his vision for future research that could revolutionize how we approach aging and disease.