#255 ‒ Latest therapeutics in CVD, APOE's role in Alzheimer's disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D. | The Peter Attia Drive

This podcast episode delves into familial hypercholesterolemia (FH), a prevalent genetic form of high cholesterol, shedding light on its causes, implications, and treatment strategies. It highlights the importance of early diagnosis and intervention, as well as ongoing research exploring the role of genetic defects, lipid metabolism, and innovative therapies in managing FH and related cardiovascular conditions.

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#255 ‒ Latest therapeutics in CVD, APOE's role in Alzheimer's disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.

The Peter Attia Drive

Familial Hypercholesterolemia: Prevalence, Risks, and New Therapeutic Options

Familial Hypercholesterolemia: A Comprehensive Overview

The Genetic Basis of Elevated LDL Cholesterol: Mutations in LDL Receptor, APOE-B, and PCSK9

FH Diagnosis: Beyond the Obvious Physical Signs

Understanding the Spectrum of Familial Hypercholesterolemia: From Polygenic to Monogenic Forms

The Enigmatic 5%: Unraveling the Mystery of FH Resistance

Unraveling Treatment Strategies for Familial Hypercholesterolemia: Tailoring Approaches for Children, Adults, and Sex

Child vs. Adult FH Treatment: A Complex Balancing Act

CETP Inhibitors: A Promising New Class of Drugs for Cardiovascular Disease?

The Evolution of CETP Inhibition and the HDL Hypothesis

CETP Inhibition: A Promising Therapeutic Approach for Cardiovascular Disease and Beyond

Groundbreaking Discovery: CETP Inhibition Unveils Dual Protective Effects in Septicemia and Diabetes

APOC-III Inhibitor: Unveiling the Promise of a Transformative Lipid-Lowering Therapy

CETP Inhibition: Reducing Cholesterol and Blood Pressure, Uncovering a New Longevity Gene

The Surprising Connection Between Cholesterol, Alzheimer's, and a Protein

The complex relationship between APOE, cholesterol metabolism, and cardiovascular disease

APOE4 and Inflammation in LDL Metabolism: A Complex Relationship with Clinical Implications

#255 ‒ Latest therapeutics in CVD, APOE's role in Alzheimer's disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.

The Peter Attia Drive

00:10Familial Hypercholesterolemia: Prevalence, Risks, and New Therapeutic Options

Familial Hypercholesterolemia: Prevalence, Risks, and New Therapeutic Options

07:27Familial Hypercholesterolemia: A Comprehensive Overview

Familial Hypercholesterolemia: A Comprehensive Overview

13:35The Genetic Basis of Elevated LDL Cholesterol: Mutations in LDL Receptor, APOE-B, and PCSK9

The Genetic Basis of Elevated LDL Cholesterol: Mutations in LDL Receptor, APOE-B, and PCSK9

19:24FH Diagnosis: Beyond the Obvious Physical Signs

FH Diagnosis: Beyond the Obvious Physical Signs

26:54Understanding the Spectrum of Familial Hypercholesterolemia: From Polygenic to Monogenic Forms

Understanding the Spectrum of Familial Hypercholesterolemia: From Polygenic to Monogenic Forms

33:18The Enigmatic 5%: Unraveling the Mystery of FH Resistance

The Enigmatic 5%: Unraveling the Mystery of FH Resistance

40:14Unraveling Treatment Strategies for Familial Hypercholesterolemia: Tailoring Approaches for Children, Adults, and Sex

Unraveling Treatment Strategies for Familial Hypercholesterolemia: Tailoring Approaches for Children, Adults, and Sex

46:31Child vs. Adult FH Treatment: A Complex Balancing Act

Child vs. Adult FH Treatment: A Complex Balancing Act

53:38CETP Inhibitors: A Promising New Class of Drugs for Cardiovascular Disease?

CETP Inhibitors: A Promising New Class of Drugs for Cardiovascular Disease?

1:02:04The Evolution of CETP Inhibition and the HDL Hypothesis

The Evolution of CETP Inhibition and the HDL Hypothesis

1:11:17CETP Inhibition: A Promising Therapeutic Approach for Cardiovascular Disease and Beyond

CETP Inhibition: A Promising Therapeutic Approach for Cardiovascular Disease and Beyond

1:19:25Groundbreaking Discovery: CETP Inhibition Unveils Dual Protective Effects in Septicemia and Diabetes

Groundbreaking Discovery: CETP Inhibition Unveils Dual Protective Effects in Septicemia and Diabetes

1:26:45APOC-III Inhibitor: Unveiling the Promise of a Transformative Lipid-Lowering Therapy

APOC-III Inhibitor: Unveiling the Promise of a Transformative Lipid-Lowering Therapy

1:33:30CETP Inhibition: Reducing Cholesterol and Blood Pressure, Uncovering a New Longevity Gene

CETP Inhibition: Reducing Cholesterol and Blood Pressure, Uncovering a New Longevity Gene

1:41:23The Surprising Connection Between Cholesterol, Alzheimer's, and a Protein

The Surprising Connection Between Cholesterol, Alzheimer's, and a Protein

1:47:55The complex relationship between APOE, cholesterol metabolism, and cardiovascular disease

The complex relationship between APOE, cholesterol metabolism, and cardiovascular disease

1:54:13APOE4 and Inflammation in LDL Metabolism: A Complex Relationship with Clinical Implications

APOE4 and Inflammation in LDL Metabolism: A Complex Relationship with Clinical Implications