This podcast episode highlights metabolic disease, the fourth of aging's "four horsemen" and its links to cardiovascular disease, cancer, and neurodegenerative diseases. The podcast defines and explores metabolic health, discussing metrics for assessment. It emphasizes the limitations of BMI and the importance of assessing body composition and insulin sensitivity to accurately reflect metabolic health at an individual level. By understanding and improving metabolic health, we can potentially reduce the risk of chronic diseases associated with aging.