This Yoga Medicine Podcast episode, co-hosted by Tiffany Cruikshank and Katja Bartsch, critically examines mindfulness research. The hosts begin by defining mindfulness, highlighting the varying interpretations in research studies, and then delve into the methodology of Mindfulness-Based Stress Reduction (MBSR) programs, noting the significant time commitment (45 minutes daily for eight weeks) and the potential for bias in self-reported data. They discuss challenges in research methodology, such as the lack of consistent definitions and the influence of social desirability bias on self-reported outcomes. Finally, they address contraindications and adverse events associated with mindfulness practices, emphasizing the importance of responsible application and referral to healthcare professionals when necessary, particularly for individuals with pre-existing mental health conditions. Listeners gain a nuanced understanding of mindfulness research and its limitations, enabling more informed application of mindfulness practices.