The Immune team discusses a paper describing the negative effects of old B cells on T cells and longevity and a snippet on an interesting vaccine approach to promote competition between gut commensals.

Hosts: Vincent Racaniello, Cindy Leifer, Stephanie Langel, and Brianne Barker

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Vaccine enhanced competition of gut bacteria (Science 2025)
B cells drive immunosenescence and aging (Sci Immunol 2026)
Time stamps by Jolene Ramsey. Thanks!

Music by Tatami.
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Immune102: Living longer without B cells

Immune