67: Da DO2: Fundamental ECMO Physiology with Sage Whitmore

This podcast explores the physiology of ECMO, focusing on oxygen delivery and consumption in the body. Sage Whitmore explains the DO2-VO2 relationship, emphasizing how ECMO replaces native oxygen delivery by manipulating flow and maintaining hemoglobin saturation. The discussion covers scenarios like cardiac arrest and cardiogenic shock, detailing how ECMO supports oxygenation and blood pressure. Whitmore addresses the challenges of North-South syndrome, the impact of non-pulsatile flow on renal function, and optimal hemoglobin levels for ECMO patients. The podcast also investigates the use of pressure monitors to detect cannula issues and the importance of LV venting to prevent ventricular overload.