Stand-up comedian and philosopher Myq Kaplan has built a successful career exploring the human condition, but navigating his own underlying anxiety presents a very different challenge. He knows how to handle recreational and spiritual psychedelic trips in the jungles of Peru, but the leap to "crossing the streams" and using these substances in a formal, clinical therapeutic setting feels uncertain. On this episode: How To!'s Mike Pesca brings on Dr. Will Van Derveer, a veteran psychiatrist, co-founder of the Integrative Psychiatry Institute, and author of Psychedelic Therapy. Dr. Will Van Derveer offers Myq guidance on using medicines like ketamine and psilocybin to "shake the snow globe" of the brain's default mode network, the importance of treating the therapy like a psychological tow truck rather than a permanent ride—and why you really need to stop bothering the Sonoran Desert toads.

Executive Producer Corey Wara

Edited by Geoff Craig

Booking by Ben Astaire

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How To Take Psychedelics for Your Mental Health with Dr. Will Van Derveer

How To! with Mike Pesca