In this “Ask Me Anything” (AMA) episode, Peter answers listener questions that pull back the curtain on how he actually thinks and operates across a wide range of topics in health and longevity. He explores whether biological aging clocks are truly trustworthy and how to assess if you’re aging well, how he thinks about seed oils, and the areas of research that most excite him right now, including cognitive health, GLP-1–based therapies, and other emerging interventions. Peter also dives into the potential upside of GLP-1s beyond weight loss and what evidence would justify broader use, explains why transcranial magnetic stimulation is on his radar, and shares his framework for evaluating body fat percentage. He walks through how he onboards a new patient without overwhelming them, reflects on the highest-leverage changes in his own life and the biggest training mistakes he’s made, and discusses sun exposure, skin cancer risk, photoaging, vitamin D, and circadian rhythm. Finally, he covers what he’s changed his mind on recently, explains why he doesn't put much stock in "blue zones," and much more.
Full show notes can be found here: http://peterattiamd.com/ama81/
We discuss:

The value of biological aging tests, and why physical performance remains the most reliable marker [2:30];
Seed oils: evaluating the evidence and separating dietary quality from ingredient fear [6:45];
Emerging therapies Peter is excited about: lithium orotate for Alzheimer’s disease, potential geroprotective benefits of GLP-1s, transcranial magnetic stimulation, and more [9:30];
Body fat percentage and longevity: balancing metabolic health, fat distribution, performance goals, and individual set points [16:45];
Explaining metabolic flexibility and how it can be improved [20:30];
How Peter onboards new patients, and how he thinks about the relative influence of genetics versus lifestyle on longevity and disease risk [24:30];
The potential for AI to improve medicine [30:00];
Valuable lessons Peter has learned from training mistakes [33:15];
Balancing the risks and benefits of sun exposure [35:30];
Specific examples of what Peter is doing to prepare for his Centenarian Decathlon [39:30];
Strong convictions loosely held: evolving views on GLP-1 cardiovascular benefits, zone 2 training misconceptions, sauna temperature, and practical recovery priorities [43:30];
Blue Zones under scrutiny: statistical outliers, data reliability concerns, genetics, and separating longevity correlation from causation [48:15]; and
More.

#383 ‒ AMA #81: Biological aging tests, longevity training, emerging therapies, GLP-1 RAs, sun exposure, and more

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