Diagnosis and Management of Lupus and Related Complications *ACPE-Accredited*

The podcast episode addresses systemic lupus erythematosus (SLE), commonly known as lupus, an autoimmune disorder characterized by multi-system inflammation and a relapsing-remitting course. The discussion covers the unclear etiology of lupus, highlighting proposed mechanisms involving immune complex buildup due to malfunctions in apoptosis and T cell effectiveness. Risk factors such as being female, childbearing age, vitamin D deficiency, silica dust exposure, and estrogen therapy are examined. Diagnostic criteria, including the 2019 European League Against Rheumatism and American College of Rheumatology classification, are detailed, emphasizing the requirement of a positive anti-nuclear antibody (ANA) titer and additive weighted clinical criteria. Treatment options like hydroxychloroquine, methotrexate, azathioprine, and biologics are reviewed, focusing on managing symptoms and preventing organ dysfunction.