This podcast episode explores the challenges and advancements in organ transplantation. It discusses the real-life case of a young patient who required a double lung transplant and later experienced rejection, highlighting the life-saving potential and ongoing struggles in this field. The episode goes beyond challenges to present potential solutions, such as machine perfusion, which enables extended organ preservation, repair, and genetic modification to improve compatibility and reduce rejection. The speaker expresses optimism about the future of organ transplantation as machine perfusion continues to evolve.