Most Replayed Moment: Can Creatine Offset Sleep Deprivation? Is It Really The Best Supplement?

The discussion centers on the benefits of creatine supplementation, particularly its impact on both muscle and brain function. Dr. Rhonda Patrick clarifies that creatine, produced naturally by the liver and brain, enhances energy production, benefiting muscle mass, strength, and cognitive performance, especially under stress. While 5 grams daily is sufficient for muscle saturation, 10-20 grams can boost brain creatine levels, potentially negating cognitive deficits from sleep deprivation. Addressing misconceptions, Dr. Patrick cites a 2025 study refuting claims of hair loss and downplays water weight gain concerns. The conversation shifts to fasting, distinguishing it from calorie restriction, with fasting activating autophagy for cellular repair, improving glucose levels and blood pressure regulation.