The podcast explores the neural mechanisms underlying navigation, focusing on how the brain enables spatial awareness and orientation. It details the functions of place cells in the hippocampus, which act as a "you are here" system, and head direction cells, which serve as the brain's compass. Grid cells in the entorhinal cortex are examined for their role in path integration and distance tracking. The discussion covers border cells and their response to navigational barriers. It also presents research on how these spatial systems are co-opted for non-spatial cognitive tasks, such as representing social status, conceptual spaces, and decision-making processes. Behavioral experiments in rodents and humans illustrate how geometric cues dominate reorientation, even when other salient landmarks are available.
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