A comprehensive review on heart failure with preserved ejection fraction (HFpEF)

This podcast features Dr. James Rudd interviewing Dr. Harriette Van Spall about heart failure with preserved ejection fraction (HFpEF). Dr. Van Spall defines HFpEF as a clinical syndrome with heart failure signs and symptoms alongside an LV ejection fraction of 50% or greater, emphasizing the complex interplay of cardiac and non-cardiac abnormalities. The discussion covers diagnostic approaches like the H2-F-PEF score, while also noting limitations and the importance of identifying HFpEF mimickers such as cardiac amyloidosis. Management strategies, including often underappreciated lifestyle interventions like weight loss and exercise, are examined alongside medical therapies such as SGLT2 inhibitors, with focus on integrated, multidisciplinary care.